For stubborn skin conditions such as foot/hand itch and ringworm, Nixoderm treatment would be required over a considerable period of time albeit the skin surface seems to be healed. This is to allow time for Nixoderm treatment to destroy the germs, parasite and fungus burrow deep under the skin surface to prevent their re-emergence. Hence, it is recommended to continue apply Nixoderm treatment for another two to three weeks after the skin seems to be well.